儿童期受虐对大学生抑郁症状的影响:主观幸福感的中介和基因的调节作用

doi:10.16187/j.cnki.issn1001-4918.2023.02.14

摘要/Abstract

摘要： 基于抑郁的差别易感性模型,以301名大学生(年龄=19.15±0.63岁,年龄范围为17~20岁)为研究对象,并引入关键环境因素(儿童期受虐和主观幸福感)和重要位点(MAOA基因rs6323和TPH2基因rs17110747)构建有调节的中介模型,探究大学生抑郁发生发展机制。结果表明:(1)儿童期受虐与大学生抑郁症状呈显著正相关,主观幸福感与儿童期受虐和大学生抑郁症状显著负相关;(2)主观幸福感在儿童期受虐对大学生抑郁症状的影响中起完全中介作用;(3)MAOA基因rs6323和TPH2基因rs17110747多态性在主观幸福感与大学生抑郁症状中起调节作用,具体表现为,相比携带rs6323位点G/G与T/T纯合子和rs17110747位点G/G与G/A基因型,携带rs6323位点G/T和rs17110747位点A/A基因型个体主观幸福感对抑郁症状的负向预测更强。

关键词: 儿童期受虐, 主观幸福感, 大学生抑郁症状, MAOA基因rs6323, TPH2基因rs17110747

Abstract: The current study constructed a moderated mediation model exploring the relationship among childhood maltreatment on college students’ depressive symptoms. A total of 301 college students (74 boys and 227 girls) participated in this investigation. After given informed consents, they completed Center for Epidemiological Studies Depression Scale, The Chinese Version of Childhood Trauma and Questionnaire and Subjective Well-being Scale. Professional nurses extracted 2.5-ml venous blood in EDTA anticoagulant tube (blood∶EDTA = 5∶1) from the participants in the study, then placed it in the refrigerator (-70 ℃), and extracted DNA and parting after three months. The results indicated that: (1) Childhood maltreatment was significantly positively correlated with college students’ depressive symptoms, and subjective well-being was significantly negatively correlated with childhood maltreatment and college students’ depressive symptoms; (2) Subjective well-being played a mediating role in the relationship between childhood maltreatment and college students’ depressive symptoms; (3) MAOA gene rs6323 homozygous G/G than G/T and T/T carriers reduced suffering from depression. MAOA gene rs6323 and TPH2 gene rs17110747 polymorphism moderated the indirect path from subjective well-being and college students’ depressive symptoms. Compared with rs6323 polymorphism G/G and T/T (rs17110747 polymorphism G/G and G/T) genotypes, subjective well-being of individuals with G/T (A/A) genotype had a stronger negative prediction of depressive symptoms.

Key words: childhood maltreatment, subjective well-being, college students’ depressive symptoms, MAOA gene rs6323, TPH2 gene rs17110747

中图分类号:

B844

曾子豪, 彭丽仪, 詹林, 刘双金, 欧阳晓优, 丁道群, 黎志华, 胡义秋, 方晓义. 儿童期受虐对大学生抑郁症状的影响:主观幸福感的中介和基因的调节作用[J]. 心理发展与教育, 2023, 39(2): 276-285.

ZENG Zihao, PENG Liyi, ZHAN Lin, LIU Shuangjin, OUYANG Xiaoyou, DING Daoqun, LI Zhihua, HU Yiqiu, FANG Xiaoyi. The Effect of Childhood Maltreatment on College Students’ Depressive Symptoms: The Mediating Role of Subjective Well-being and the Moderation Role of Gene[J]. Psychological Development and Education, 2023, 39(2): 276-285.

参考文献

Aghababaei, N., Bragatti, J. A., Bandeira, I. C., de Carvalho, A. M., Abujamra, A. L., Leistner-Segal, S.,&Bianchin, M. M.(2014). Tryptophan hydroxylase 2(TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.Epilepsy&Behavior, 32, 59-63.
Agnew-Blais, J.,&Danese, A.(2016). Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder:A systematic review and meta-analysis. The Lancet Psychiatry, 3(4), 342-349.
Badr, H. E., Naser, J., Al-Zaabi, A., Al-Saeedi, A., Al-Munefi, K., Al-Houli, S.,&Al-Rashidi, D.(2018). Childhood maltreatment:A predictor of mental health problems among adolescents and young adults. Child Abuse&Neglect, 80, 161-171.
Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P.,&Philibert, R. A.(2010). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.Journal of Family Psychology, 24(1), 12-20.
Beck, A. T.,&Weishaar, M. E.(2000). Cognitive therapy. In R. J. Corsini&D. Wedding (Eds.),Current psychotherapies(pp. 241-272). Itasca, IL:F.E. Peacock.
Belmaker, R. H.,&Agam, G.(2008). Mechanisms of disease:Major depressive disorder.The New England Journal of Medicine, 358(1), 55-68.
Bland, J. M.,&Altman, D. G.(1997). Statistics notes:Cronbach's alpha. BMJ, 314, 572.
Byrd, A. L.,&Manuck, S. B.(2014). MAOA, childhood maltreatment, and antisocial behavior:Meta-analysis of a gene-environment interaction.Biological Psychiatry, 75(1), 9-17.
Capistrant, B. D., Friedemann-Sánchez, G., Novak, L. K., Zuijdwijk, C., Ogle, G. D.,&Pendsey, S.(2017). Mental health and well-being among type 1 diabetes caregivers in India:Evidence from the IDREAM study.Diabetes Research and Clinical Practice, 134, 168-177.
Caspi, A.(2003). Influence of life stress on depression:Moderation by a polymorphism in the 5-htt gene.Science, 301(5631), 386-389.
Cicchetti, D., Rogosch, F. A.,&Sturge-Apple, M. L.(2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase a polymorphisms:Depressive symptomatology among adolescents from low socioeconomic status backgrounds.Development and Psychopathology, 19(04), 1161-1180.
Cohen, J.(1988).Statistical power analysis for the behavioral sciences. Routledge.
Comasco, E., Sylvén, S. M., Papadopoulos, F. C., Sundström-Poromaa, I., Oreland, L.,&Skalkidou, A.(2011). Postpartum depression symptoms:A case-control study on monoaminergic functional polymorphisms and environmental stressors.Psychiatric Genetics, 21(1), 19-28.
Diener, E., Suh, E. M., Lucas, R. E.,&Smith, H. L.(1999). Subjective well-being:three decades of progress. Psychological Bulletin, 125(2), 276-302.
Dunn, E. C., Uddin, M., Subramanian, S. V., Smoller, J. W., Galea, S.,&Koenen, K. C.(2011). Research review:Gene-environment interaction research in youth depression-a systematic review with recommendations for future research.Journal of Child Psychology and Psychiatry, 52(12), 1223-1238.
Fan, M., Liu, B., Jiang, T., Jiang, X., Zhao, H.,&Zhang, J.(2010). Meta-analysis of the association between the monoamine oxidase-a gene and mood disorders.Psychiatric Genetics, 20(1), 1-7.
Felitti, V. J., Anda, R. F, Nordenberg, D., Williamson, D. F.,&Marks, J. S.(2019). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults:The adverse childhood experiences (ace) study.American Journal of Preventive Medicine, 56(6), 774-786.
Gilman, S. E., Sucha, E., Kingsbury, M., Horton, N. J., Murphy, J. M.,&Colman, I.(2017). Depression and mortality in a longitudinal study:1952-2011.Canadian Medical Association journal. 189(42), E1304-E1310.
Greger, H. K., Myhre, A. K., Klöckner, C. A.,&Jozefiak, T.(2017). Childhood maltreatment, psychopathology and well-being:The mediator role of global self-esteem, attachment difficulties and substance use. Child Abuse&Neglect, 70, 122-133.
Hammen, C.(2018). Risk factors for depression:An autobiographical review. Annual Review of Clinical Psychology, 14, 1-28.
Jansson, M., McCarthy, S., Sullivan, P. F., Dickman, P., Andersson, B., Oreland, L., … Pedersen, N. L.(2005). MAOA haplotypes associated with thrombocyte-MAO activity. BMC Genetics, 6(1), 46.
Jaye Capretto, J.(2020). Developmental timing of childhood physical and sexual maltreatment predicts adult depression and post-traumatic stress symptoms.Journal of Interpersonal Violence, 35(13-14), 2558-2582.
Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., … Gelemter, J.(2006). Brain-derived neurotrophic factor-5-httlpr gene interactions and environmental modifiers of depression in children.Biological Psychiatry, 59(8), 673-680.
Kifer, Y., Heller, D., Perunovic, W. Q. E.,&Galinsky, A. D.(2013). The good life of the powerful:The experience of power and authenticity enhances subjective well-being.Psychological Science, 24(3), 280-288.
Lamela, D., Jongenelen, I., Morais, A.,&Figueiredo, B.(2017). Cognitive-affective depression and somatic symptoms clusters are differentially associated with maternal parenting and coparenting.Journal of Affective Disorders, 219, 37-48.
Moreno, R. L., Godoy-Izquierdo, D., Vazquez Perez, M. L., García, A. P., Araque Serrano, F.,&Godoy Garcia, J. F.(2014). Multidimensional psychosocial profiles in the elderly and happiness:A cluster-based identification.Aging&Mental Health, 18(4), 489-503.
Nabavi, S. M., Daglia, M., Braidy, N.,&Nabavi, S. F.(2015). Natural products, micronutrients, and nutraceuticals for the treatment of depression:A short review.Nutritional Neuroscience, 20(3), 180-194.
Nanni, V., Uher, R.,&Danese, A.(2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression:A meta-analysis.American Journal of Psychiatry, 169(2), 141-151.
Natsuaki, M. N., Biehl, M. C.,&Ge, X. J.(2010). Trajectories of depressed mood from early adolescence to young adulthood:The effects of pubertal timing and adolescent dating.Journal of Research on Adolescence, 19(1), 47-74.
Nelson, J., Klumparendt, A., Doebler, P.,&Ehring, T.(2017). Childhood maltreatment and characteristics of adult depression:Meta-analysis.The British Journal of Psychiatry, 210(2), 96-104.
Nikulina, V., Widom, C. S.,&Brzustowicz, L. M.(2011). Child abuse and neglect, monoamine oxidase a, and mental health outcomes:A prospective examination.Biological Psychiatry, 71(4),350-357.
Ottenhof, K. W., Sild, M., Lévesque, M. L., Ruhé, H. G.,&Booij, L.(2018). TPH2 polymorphisms across the spectrum of psychiatric morbidity:A systematic review and meta-analysis. Neuroscience&Biobehavioral Reviews, 92, 29-42.
Rivera, M., Gutiérrez, B., Molina, E., Torres-González, F., Bellón, J. A., Moreno-küstner, B., … Cervilla, J. A.(2009). High-activity variants of the umaoa polymorphism increase the risk for depression in a large primary care sample.American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics:The Official Publication of the International Society of Psychiatric Genetics, 150B(3), 395-402.
Seligman, M. E. P.(2008). Positive health. Applied Psychology:An International Review, 57, 3-18.
Sheikh, M. A., Abelsen, B.,&Olsen, J. A.(2016). Differential recall bias, intermediate confounding, and mediation analysis in life course epidemiology:An analytic framework with empirical example.Frontiers in Psychology, 7, 1828.https://doi.org/10.3389/fpsyg.2016.01828
Sijtsma, K.(2009). On the use, the misuse, and the very limited usefulness of Cronbach's alpha.Psychometrika, 74(1), 107-120.
Smith, K.(2014). Mental health:A world of depression.Nature, 515, 180-181.
Starr, L. R., Hammen, C., Conway, C. C., Raposa, E.,&Brennan, P. A.(2014). Sensitizing effect of early adversity on depressive reactions to later proximal stress:Moderation by 5-HTTLPR and CRHR1 in a 20-year longitudinal study.Development and Psychopathology, 26(4Pt2), 1241-1254.
Tao, S., Chattun, M. R., Yan, R., Geng, J., Zhu, R., Shao, J., … Yao, Z.(2018). TPH-2 gene polymorphism in major depressive disorder patients with early-wakening symptom.Frontiers in Neuroscience, 12, 827.https://doi.org/10.3389/fnins.2018.00827
Teicher, M. H., Samson, J. A., Anderson, C. M.,&Ohashi, K.(2016). The effects of childhood maltreatment on brain structure, function and connectivity.Nature Reviews Neuroscience, 17(10), 652-666.
Tsai, S. J., Hong, C. J., Liou, Y. J., Younger, W. Y., Chen, T. J., Hou, S. J.,&Yen, F. C.(2009). Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(4), 637-641.
Wichers, M., Jacobs, N., Derom, C., Thiery, E.,&van Os, J.(2007). Depression:Too much negative affect or too little positive affect?Twin Research and Human Genetics, 10(S1), 19-20.
Yang, W., Xiong, G., Garrido, L. E., Zhang, J. X., Wang, M. C.,&Wang, C.(2018). Factor structure and criterion validity across the full scale and ten short forms of the CES-D among Chinese adolescents.Psychological Assessment, 30(9), 1186-1198.
Zhang, L., Li, Z., Chen, J., Li, X., Zhang, J.,&Belsky, J.(2016). The bdnf val66met polymorphism interacts with maternal parenting influencing adolescent depressive symptoms:Evidence of differential susceptibility model.Journal of Youth and Adolescence, 45(3), 471-483.
温忠麟,叶宝娟.(2014).有调节的中介模型检验方法:竞争还是替补?心理学报, 46(5), 714-726.
吴艳,温忠麟.(2011).结构方程建模中的题目打包策略.心理科学进展, 19(12), 1859-1867.
于增艳,赵阿勐,刘爱书.(2017).儿童期受虐经历与抑郁的元分析. 心理学报, 49(1), 40-49.
张洁旭,陈彦博,张克让,许琪,沈岩.(2009).单胺氧化酶A启动子可变数目重复序列多态性与中国北方汉族人群重性抑郁症的关联分析. 中国医学科学院学报, 31(6), 728-734.
张连云.(2006).抑郁、社会支持对师范大学生主观幸福感的影响. 中国健康心理学杂志,(05), 117-119.
赵幸福,张亚林,李龙飞,周云飞.(2005).儿童期虐待问卷中文版的信度及效度评估.中国临床康复,(16), 209-211.
中华人民共和国国家卫生健康委员会.(2020).国家卫生健康委办公厅关于探索开展抑郁症、老年痴呆防治特色服务工作的通知.取自http://www.nhc.gov.cn/jkj/s7914/202009/a63d8f82eb53451f97217bef0962b98f.shtml.

多维度评价

Viewed

Full text

Abstract

Cited

Shared

Discussed

[1]	唐莹莹, 蔺秀云, 殷锦绣, 何婷, 周少嘉, 曹志涛. 亲子依恋和祖孙依恋的一致与不一致和儿童主观幸福感的关系[J]. 心理发展与教育, 2023, 39(6): 859-868.
[2]	彭海云, 盛靓, 邱凡硕, 周姿言, 辛素飞. 青少年心理减负从“无聊”开始——无聊倾向对青少年主观幸福感的影响机制[J]. 心理发展与教育, 2023, 39(6): 895-902.
[3]	田玮宜, 徐健捷, 吕广林, 王轶楠. 父母自尊与青少年主观幸福感间的关系:亲子信任与青少年自尊的链式中介作用[J]. 心理发展与教育, 2022, 38(3): 331-338.
[4]	陈必忠, 郑雪, 孙晓军. 社交媒体自我控制失败影响硕士生主观幸福感的心理机制[J]. 心理发展与教育, 2021, 37(6): 882-888.
[5]	袁柯曼, 李白璐, 梁丽婵, 边玉芳. 累积情境风险与流动儿童主观幸福感的关系:个体保护因子的补偿效应和保护效应[J]. 心理发展与教育, 2021, 37(4): 546-557.
[6]	牛凯宁, 李梅, 张向葵. 青少年友谊质量和主观幸福感的关系:一项元分析[J]. 心理发展与教育, 2021, 37(3): 407-418.
[7]	陈子循, 王晖, 冯映雪, 刘霞. 同伴侵害对留守青少年主观幸福感的影响:自尊和社会支持的作用[J]. 心理发展与教育, 2020, 36(5): 605-614.
[8]	池文韬, 桑青松, 舒首立. 大学生专业内部动机与主观幸福感的关系:专业投入与主观专业成就的中介作用[J]. 心理发展与教育, 2020, 36(4): 477-485.
[9]	衡书鹏, 赵换方, 牛更枫, 周宗奎. 朋友圈点赞与主观幸福感的关系:一个有中介的调节模型[J]. 心理发展与教育, 2020, 36(3): 341-349.
[10]	郭瑾瑾, 牛璐, 谢笑春, 王鹏程, 雷雳. 线上“秀恩爱”与旁观者主观幸福感的关系:自尊的中介作用和依恋的调节作用[J]. 心理发展与教育, 2020, 36(3): 359-366.
[11]	吴玉婷, 苑鑫, 王雨晴, 朱慧, 毛叶琳, 金灿灿. 广场舞组织氛围和老年人主观幸福感的关系:组织认同和自尊的中介作用[J]. 心理发展与教育, 2019, 35(5): 624-631.
[12]	张兴旭, 郭海英, 林丹华. 亲子、同伴、师生关系与青少年主观幸福感关系的研究[J]. 心理发展与教育, 2019, 35(4): 458-466.
[13]	牛玉柏, 郝泽生, 王任振, 洪芳. 老年人乐观、领悟社会支持与主观幸福感的关系—控制策略的中介作用[J]. 心理发展与教育, 2019, 35(2): 227-235.
[14]	连坤予, 谢姗姗, 林荣茂. 中小学教师职业人格与主观幸福感的关系:工作投入的中介作用[J]. 心理发展与教育, 2017, 33(6): 700-707.
[15]	孟男, 王玉慧, 雷雳. 自拍照编辑与女大学生主观幸福感的关系:积极反馈与自我概念的中介作用[J]. 心理发展与教育, 2017, 33(6): 751-758.