心理发展与教育 ›› 2025, Vol. 41 ›› Issue (4): 518-527.doi: 10.16187/j.cnki.issn1001-4918.2025.04.08

• 心理健康与教育 • 上一篇    下一篇

母亲拒绝与多巴胺基因对学前儿童外化问题的联合作用:努力控制的近端机制

邢淑芬1, 白荣2, 刘霞2, 李森3   

  1. 1. 首都师范大学心理学院, 北京 100048;
    2. 北京师范大学发展心理研究院, 北京 100875;
    3. 河北大学教育学院, 河北 071002
  • 发布日期:2025-07-12
  • 通讯作者: 李森 E-mail:1447123652@qq.com
  • 基金资助:
    国家自然科学基金面上项目(32171069);河北省教育科学研究“十四五”规划课题(2102075)

Combined Effects of Maternal Rejection and Dopaminergic Polygenes on Externalizing Behavior in Preschoolers: A Proximal Mechanism of Effortful Control

XING Shufen1, BAI Rong2, LIU Xia2, LI Sen3   

  1. 1. School of Psychology, Capital Normal University, Beijing 100048;
    2. Institute of Developmental Psychology, Beijing Normal University, Beijing 100875;
    3. School of Education, Hebei University, Hebei 071002
  • Published:2025-07-12

摘要: 选取山东和河北农村地区两所幼儿园中的285名学前儿童及其母亲为研究对象,由母亲报告其拒绝行为、儿童外化问题和努力控制,使用唾液采集儿童基因数据,采用多基因累加得分研究范式考察母亲拒绝与多巴胺基因对学前儿童外化问题的作用及机制。控制儿童性别、年龄和父母受教育程度后,结果发现:(1)母亲拒绝显著正向预测儿童外化问题;(2)母亲拒绝与多巴胺基因累加得分对儿童外化问题的交互作用显著,符合“素质压力模型”,即相比多基因累加得分较高的儿童,得分较低的儿童在经历母亲拒绝后外化问题更多;(3)母亲拒绝与多巴胺基因累加得分对儿童外化问题的交互效应通过儿童努力控制产生作用。研究结果为该领域的理论发展和干预研究提供了支持。

关键词: 母亲拒绝, 多巴胺基因累加得分, 努力控制, 外化问题, 学前儿童

Abstract: Two hundred and eighty-five preschool children and their mothers were recruited as participants to examine the effect and mechanism of maternal rejection and dopaminergic genes on children’s externalizing behavior. Mothers reported their rejective parenting behaviors, children’s externalizing behaviors, and effortful control. Children’s dopaminergic genes were typed by collecting saliva. After controlling children’s sex, age, and parental education levels, results showed that: (1) Maternal rejection was a significant predictor of children’s externalizing behavior; (2) There was a significant interaction between maternal rejection and dopamine polygenic cumulative scores on children’s externalizing behaviors. The interaction was in line with the “diathesis-stress model”. That is, compared with children with higher polygenic cumulative scores, children with lower scores showed more externalizing behaviors when experienced maternal rejection; (3) The mediating role of children’s effortful control was significant in the above interaction. These findings provide support for theoretical development and intervention research in the field.

Key words: maternal rejection, dopamine polygenic cumulative score, effortful control, externalizing behavior, preschooler

中图分类号: 

  • B844
Achenbach, T. M., & Edelbrock, C. S. (1983). Taxonomic issues in child psychopathology.In Handbook of child psychopathology (pp. 65-93). Springer, Boston, MA.
Allegrini, A.G., Evans, B. E., Rooij, S. D., Greaves-Lord, K., & Huizink, A. C. (2017). Gene×environment contributions to autonomic stress reactivity in youth. Development and Psychopathology, 31(1), 293-307.
Alvim-soares, A., Miranda, D., Campos, S. B., Figueira, P., Romanosilva, M. A., & Correa, H. (2013). Postpartum depression symptoms associated with Val158Met COMT polymorphism.Archives of Women's Mental Health, 16(4), 339-340.
Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2011). Differential susceptibility to rearing environment depending on dopamine-related genes:New evidence and a meta-analysis.Development and Psychopathology, 23(01), 39-52.
Beauchaine, T.P., & Gatzke-Kopp, L. M. (2012). Instantiating the multiple levels of analysis perspective in a program of study on externalizing behavior. Development & Psychopathology, 24(03), 1003-1018.
Beaver, K. M., Wright, J. P., Delisi, M., Daigle, L. E., & Gibson, C. L. (2008). Evidence of a gene x environment interaction in the creation of victimization:Results from a longitudinal sample of adolescents. International Journal of Offender Therapy and Comparative Criminology, 51(6), 620-645.
Belsky, J. (1997). Theory testing, effect-size evaluation, and differential susceptibility to rearing influence:The case of mothering and attachment. Child Development, 68(4), 598-600.
Border,R., & Keller, M. C. (2017). Commentary:Fundamental problems with candidate gene-by-environment interaction studies-reflections on Moore and Thoemmes (2016). Journal of Child Psychology & Psychiatry, 58(3), 328-330.
Bulik-Sullivan, B. K., Loh, P. R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., … Schizophrenia Working Group of the Psychiatric Genomics Consortium. (2015). LD Score regression distinguishes confounding from polygenicity in genome-wide association studies.Nature Genetics, 47(3), 291-295.
Chen, B., & Volling, B. L. (2023). Paternal and maternal rejection and Chinese children's internalizing and externalizing problems across the transition to siblinghood:A developmental cascade model of family influence.Child Development, 94(1), 288-302.
Chhangur, R. R., Weeland, J., Overbeek, G., Matthys, W., Orobio de Castro, B., van der Giessen, D., & Belsky, J. (2017). Geneticmoderation of intervention efficacy:Dopaminergic genes, the incredible years, and externalizing behavior in children. Child Development, 88(3), 796-811.
Delisi, M., Beaver, K. M., Wright, J. P., & Vaughn, M. G. (2008). The etiology of criminal onset:The enduring salience of nature and nurture. Journal of Criminal Justice, 36(3), 217-223.
Dalton, E. D., Hammen, C. L., Najman, J. M., & Brennan, P. (2014). Genetic susceptibility to family environment:BDNF Val66met and 5-HTTLPR influence depressive symptoms.Journal of Family Psychology, 28(6), 947-956.
Davies, P. T., Pearson, J. K., Cicchetti, D., Martin, M. J., Cummings, E. M., & Beauchaine, T. P. (2019). Emotional insecurity as a mediator of the moderating role of dopamine genes in the association between interparental conflict and youth externalizing problems.Development & Psychopathology, 31(3), 1111-1126.
Davies, P., Cicchetti, D., & Hentges, R. F. (2015). Maternal unresponsiveness and child disruptive problems:The interplay of uninhibited temperament and dopamine transporter genes.Child Development, 86(1), 63-79.
Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., … Weinberger, D. R. (2001). Effect of comt val108/158 met genotype on frontal lobe function and risk for schizophrenia.Proceedings of the National Academy of Sciences of the United States of America, 98(12), 6917-6922.
Endendijk, J. J., Groeneveld, M. G., & Mesman, J. (2018). Thegendered family process model:An integrative framework of gender in the family. Archives of Sexual Behavior, 47(4), 877-904.
Fischer, K., Weeland, J., Leijten, P., van den Akker, A., & Overbeek, G. (2020). Current andfuture perspectives on children's genetic- and endophenotype-based differential susceptibility to parenting. Journal of Child & Family Studies, 29(3), 773-779.
Gao, Y. M., Xiong, Y. K., Liu, X., Liu, J. M., Li, J. W., & Wang, H. (2022). Examining how and why polygenic dopamine composite levels moderate adolescents' vulnerability to peer victimization. Child and Adolescence Psychiatry and Mental Health, 16, Article 84. https://doi.org/10.1186/s13034-022-00521-7
Hanson, J. L., Adluru, N., Chung, M. K., Alexander, A. L., Davidson, R. J., & Pollak, S. D. (2013). Early neglect is associated with alterations in white matter integrity and cognitive functioning.Child Development, 84(5), 1566-1578.
Hasan, A., & Afzal, M. (2019). Gene and environment interplay in cognition:Evidence from twin and molecular studies, future directions and suggestions for effective candidate gene×environment (c G×E) research. Multiple Sclerosis & Related Disorders, 33, 121-130.
Hay, C., & Forrest, W. (2006). The development of self-control:Examining self-control theory's stability thesis. Criminology, 44(4), 739-774.
Heim, C., & Binder, E. B. (2012). Current research trends in early life stress and depression:Review of human studies on sensitive periods, gene-environment interactions, and epigenetics. Experimental Neurology, 233(1), 102-111.
Honomichl, R.D., & Donnellan, M.B. (2011). Dimensions of temperament in preschoolers predict risk taking and externalizing behaviors in adolescents. Social Psychological & Personality Science, 3(1), 14-22.
Hygen, B. W., Belsky, J., Stenseng, F., Lydersen, S., Guzey, I. C., & Wichstrom, L. (2015). Child exposure to serious life events, COMT, and aggression:Testing differential susceptibility theory.Development & Psychopathology, 51(8), 1098-1104.
Khaleque, A., & Rohner, R. P. (2012). Pancultural associations between perceived parental acceptance and psychological adjustment of children and adults:A meta-analytic review of worldwide research.Journal of Cross-Cultural Psychology, 43(5), 784-800.
Kiang, L., Moreno, A. J., & Robinson, J. L. (2004). Maternal perceptions about parenting predict child temperament, maternal sensitivity, and children's empathy.Developmental Psychology, 40(6), 1081-1092.
Kochanska, G., & Knaack, A. (2003). Effortful control as a personality characteristic of young children:Antecedents, correlates, and consequences. Journal of Personality, 71(6), 1087-1112.
Meyer, B. M., Huemer, J., Rabl, U., Boubela, R. N., Kalcher, K., Berger,A., … Lathrop, M. (2016). Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. Brain Structure and Function, 221(1), 103-114.
Mitchell,C., Mclanahan, S., Brooks-Gunn, J., Garfinkel, I., Hobcraft, J., & Notterman, D. (2013). Genetic differential sensitivity to social environments:Implications for research. American Journal of Public Health, 103(S1), 102-110.
Monroe, S. M., & Simons, A. D. (1991). Diathesis-stress theories in the context of life stress research:Implications for the depressive disorders. Psychological Bulletin, 110(3), 406-425.
Moore, S. R. (2017). Commentary:What is the case for candidate gene approaches in the era of high-throughput genomics? A response to Border and Keller (2017). Journal of Child Psychology & Psychiatry, 58(3), 331-334.
Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., & Hariri, A. R. (2011). Multilocus genetic profile for dopaminesignaling predicts ventral striatum reactivity. Neuropsychopharmacology, 36(9), 1940-1947.
Putnam, S. P., & Rothbart, M. K. (2006). Development of Short and Very Short Forms of the Children's Behavior Questionnaire.Journal of Personality Assessment, 87(1), 102-112.
Putnick, D. L., Bornstein, M. H., Lansford, J. E., Malone, P. S., Pastorelli, C., Skinner, A. T.,… Oburu, P. (2015). Perceived mother and father acceptance-rejection predict four unique aspects of child adjustment across nine countries. Journal of Child Psychology & Psychiatry, 56(8), 923-932.
Roddriguiz, R. M., Chu, R., Caron, M. G., & Wetsel, W. C. (2004). Aberrant responses in social interaction of dopamine transporter knockout mice.Behavioral Brain Research, 148(1-2), 185-198.
Rohner, R. P., Khaleque, A., & Cournoyer, D. E. (2005). Parental acceptance-rejection:Theory, methods, cross-cultural evidence, and implications.Ethos, 33(3), 299-334.
Roisman, G.I., Newman, D. A., Fraley, R. C., Haltigan, J. D., & Haydon, K. C. (2012). Distinguishing differential susceptibility from diathesis-stress:Recommendations for evaluating interaction effects. Development & Psychopathology, 24(2), 389-409.
Rothbart, M.K., & Posner, M. I. (2005). Genes and experience in the development of executive attention and effortful control. New Directions for Child & Adolescent Development, 2005(109), 101-108.
Sheese, B.E., Voelker, P. M., Rothbart, M. K., & Posner, M. I. (2007). Parenting quality interacts with genetic variation in dopamine receptor d4 to influence temperament in early childhood. Development & Psychopathology, 19(04), 1039-1046.
Sheikh, H.I., Kryski, K. R., Kotelnikova, Y., Hayden, E. P., & Singh, S. M. (2017). Catechol-o-methyltransferase gene (val158met) polymorphisms and anxious symptoms in early childhood:The roles of hypothalamus-pituitary-adrenal axis reactivity and life stress. Neuroscience Letters, 659, 86-91.
Stein, D. J., Newman, T. K., Savitz, J., & Ramesar, R. (2006). Warriors versus worriers:The role of COMT gene variants.CNS Spectrums, 11(10), 745-748.
Super, C.M., & Harkness, S. (1986). The developmental niche:A conceptualization at the interface of child and culture. International Journal of Behavioral Development, 9(4), 545-569.
Thibodeau, E.L., Cicchetti, D., & Rogosch, F. A. (2015). Child maltreatment, impulsivity, and antisocial behavior in african american children:moderation effects from a cumulative dopaminergic gene index. Development & Psychopathology, 27(4), 1621-1636.
Tielbeek, J. J., Johansson, A., Polderman, T. J., Rautiainen, M. R., Jansen, P., Taylor, M., … Viding, E. (2017). Genome-wide association studies of a broad spectrum of antisocial behavior.JAMA Psychiatry, 74, 1242-1250.
Tuvblad, C., Narusyte, J., Comasco, E., Andershed, H., Andershed, A.-K., Colins, O. F.,… Nilsson, K. W. (2016). Physical and verbal aggressive behavior and COMT genotype:Sensitivity to the environment. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics:The Official Publication of the International Society of Psychiatric Genetics, 171(5), 708-718.
Van Heel, M. V., Bijttebier, P., Claes, S., Colpin, H., Goossens, L., Hankin, B., …Van Leeuwen, K. (2020). Parenting, effortful control, and adolescents' externalizing problem behavior:Moderation by dopaminergic genes. Journal of Youth and Adolescence, 49(1), 252-266.
Van Heel, M. V., Bijttebier, P., Claes, S., Colpin, H., Goossens, L., Hankin, B., … Van Leeuwen, K. (2020). Parenting, effortful control, and adolescents' externalizing problem behavior:Moderation by dopaminergic genes. Journal of Youth and Adolescence, 49(1), 252-266.
Vrantsidis, D. M., Clark, C. A. C., Volk, A., Wakschlag, L. S., Andrews Espy, K., & Wiebe, S. A. (2023). Exploring the interplay of dopaminergic genotype and parental behavior in relation to executive function in early childhood.Development and Psychopathology, 35(3), 1147-1158.
Weeland, J., Overbeek, G., Castro, B. O., & Matthys, W. (2015). Underlying mechanisms of gene-environment interactions in externalizing behavior:A systematic review and search for theoretical mechanisms.Clinical Child and Family Psychology Review, 18(4), 413-442.
Wright, E. M., & Schwartz, J. A. (2021). The influence of adverse childhood experiences on internalizing and externalizing problems in early adulthood:Evidence of a gene×environment×sex interaction. Child Abuse & Neglect, 114, Article 104962. https://doi.org/10.1016/j.chiabu.2021.104962
Zhang,X., & Belsky, J. (2020). Three phases of gene×environment interaction research:Theoretical assumptions underlying gene selection. Development and Psychopathology, 34(1), 295-306.
蔡春凤, 周宗奎. (2006). 儿童外部问题行为稳定性的研究. 心理科学进展, 14(1), 66-72.
曹丛, 王美萍, 张文新, 纪林芹, 陈亮, 陈欣银. (2014). COMT基因rs6267多态性与母亲教养行为对青少年身体攻击和关系攻击的交互作用. 心理学报, 46(10), 1486-1497.
曹衍淼, 张文新. (2019). 多巴胺系统基因与母亲教养行为对青少年抑郁的影响:一项多基因研究. 心理学报, 51(10), 1102-1115.
杜亚松, 寇建华, 王秀玲, 夏黎明, 邹如皓. (2006). 长处和困难问卷研究. 心理科学, 29(6), 1419-1421.
黄林辉, 陈圆圆, 朱键军, 张卫. (2022). 父母拒绝和青少年外化问题行为的交叉滞后分析. 应用心理学, 28(2), 125-133.
林小楠, 曹衍淼, 张文新, 纪林芹. (2023). 多巴胺系统多基因与青少年攻击行为的U型关系:母亲消极教养的调节作用. 心理学报, 55(4), 588-599.
王美萍, 张文新. (2010a). COMT基因rs6267多态性与青少年攻击行为的关系:性别与负性生活事件的调节作用. 心理学报, 42(11), 1073-1081.
王美萍, 张文新. (2010b). COMT 基因多态性与攻击行为的关系. 心理科学进展, 18(8), 1256-1262.
叶宝娟, 温忠麟. (2013). 有中介的调节模型检验方法:甄别和整合. 心理学报, 45(9), 1050-1060.
[1] 徐珊珊, 黄书珍, 崔秀敏, 陈慧, 蔺秀云. 留守儿童人际敏感性与问题行为的相互作用: 个体间和个体内效应[J]. 心理发展与教育, 2025, 41(1): 86-98.
[2] 刘倩文, 高晗晶, 王振宏. 亲子关系与CLOCK基因rs1801260多态性对学前儿童亲社会行为的交互影响:性别的调节作用[J]. 心理发展与教育, 2024, 40(5): 625-635.
[3] 王玲晓, 郭明宇, 徐俊彦, 常淑敏. 同伴拒绝与青少年外化问题行为的纵向关系: 学校资源和性别的作用[J]. 心理发展与教育, 2024, 40(5): 695-705.
[4] 黄鹤, 王小英. 正念教养与学前儿童问题行为的关系:亲子关系与心理弹性的链式中介[J]. 心理发展与教育, 2024, 40(4): 533-541.
[5] 王艳辉, 沈梓锋, 赖雪芬. 父母心理控制与青少年外化问题行为的关系:意志控制和越轨同伴交往的链式中介作用[J]. 心理发展与教育, 2024, 40(2): 248-256.
[6] 冷欣怡, 苏萌萌, 李文玲, 杨秀杰, 邢爱玲, 张湘琳, 舒华. 家庭环境与农村儿童早期语言发展的关系[J]. 心理发展与教育, 2024, 40(1): 8-18.
[7] 赵京伟, 陈晓旭, 任立文, 耿喆, 徐夫真. 父母心理控制与小学儿童焦虑:一个有调节的中介模型[J]. 心理发展与教育, 2024, 40(1): 93-102.
[8] 张和颐, 洪秀敏. 家庭认知环境与0~3岁婴幼儿发展的关系:有调节的中介效应[J]. 心理发展与教育, 2022, 38(2): 178-185.
[9] 白荣, 闫嵘, 王千, 李叶, 邢淑芬. 学前儿童执行功能与问题行为的关系:情境和性别的特异性[J]. 心理发展与教育, 2022, 38(1): 35-44.
[10] 张光珍, 梁淼, 梁宗保. 父母教养方式影响学前儿童社会适应的追踪研究:自我控制的中介作用[J]. 心理发展与教育, 2021, 37(6): 800-807.
[11] 占淑玮, 杨宁, 赵必华. 留守学前儿童接受性语言能力与社会退缩的关系:有调节的中介模型[J]. 心理发展与教育, 2021, 37(6): 834-844.
[12] 陈慧, 何婷, 唐远琼, 唐怡欣, 陆风勇, 蔺秀云. 共情与青少年内外化问题的关系及影响机制[J]. 心理发展与教育, 2021, 37(3): 439-446.
[13] 王英杰, 李燕, 吴凡. 家庭功能与学前儿童行为问题的关系:依恋回避和社交焦虑的多重中介作用[J]. 心理发展与教育, 2021, 37(1): 76-83.
[14] 张凡, 赵德懋, 刘霞, 白荣, 张明亮, 邢淑芬. 父母教养与MAOA基因rs6323多态性对学前儿童外化问题的共同作用[J]. 心理发展与教育, 2020, 36(6): 659-667.
[15] 李倩倩, 姚力宁, 梁金军, 邢淑芬. 电视暴力对不同外倾性气质学前儿童社会行为的差异化影响——“一般攻击模型”与“催化剂模型”的理论之争[J]. 心理发展与教育, 2020, 36(5): 545-554.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
No Suggested Reading articles found!