Psychological Development and Education ›› 2017, Vol. 33 ›› Issue (2): 216-227.doi: 10.16187/j.cnki.issn1001-4918.2017.02.11

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The Interaction between Val158Met Polymorphism in the COMT Gene and Peer Relationship on Adolescents' Depression

CAO Yanmiao1, LIN Xiaonan1, JI Linqin1, ZHANG Yueping2, ZHANG Wenxin1   

  1. 1. School of Psychology, Shandong Normal University, Jinan 250014, China;
    2. Lewis & Clark College, Portland 97219
  • Online:2017-03-15 Published:2017-03-15

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Abstract: Catecholamine plays a central role in mood regulation and the development of depressive disorders.The present study investigated whether a functional polymorphism (Val158Met) of the catechol-O-methyltrans-ferase gene interacts with peer acceptance or peer rejection in the prediction of depression.A sample of 15 years old students (n=1,048,50% female) from a large longitudinal study of China were completed a questionnaire and gave a saliva sample for DNA extraction.When the whole population was analyzed,no main effects of COMT or peer relationship in association with depression were found.The COMT gene interacted with the two forms of peer relationships in predicting adolescent depression.Specifically,adolescents with ValVal homozygotes exhibited lower levels of depression when experiencing higher levels of peer acceptance or lower levels of peer rejection,but reported higher levels of depression when they were exposure to lower levels of peer acceptance or higher levels of peer rejection,relative to their counterparts with Met alleles.But there were no significant three-way interactions among gender,COMT gene and peer relationships on depression.When separated by gender,a significant G×E interaction effect of the ValVal genotype was found among boys.No G×E interaction effect was found among girls.The present study provides strong support for the differential susceptibility hypothesis.Besides,these findings highlight the importance of investigating the moderating role of gender and suggest that adolescent depression has complex genetic underpinnings which vary across genders.

Key words: adolescent, depression, COMT gene Val158Met polymorphism, peer acceptance/rejection, differential susceptibility, gender difference

CLC Number: 

  • B844

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