Psychological Development and Education ›› 2019, Vol. 35 ›› Issue (1): 85-94.doi: 10.16187/j.cnki.issn1001-4918.2019.01.10

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The Effect of 5-HTTLPR Polymorphism and Early Parenting Stress on Preschoolers' Behavioral Problems

LIU Yapeng1,2, DENG Huihua2, ZHANG Minghao3, ZHANG Guangzhen2, LU Zuhong2   

  1. 1. Research Group of Early Education of Disadvantaged Children, School for Preschool Education, NanJing XiaoZhuang University, Nanjing 211171;
    2. Key Laboratory of Child Development and Learning Science of Ministry of Education, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096;
    3. School of Educational Science, Ludong University, Yantai 264025
  • Published:2019-01-30

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Abstract: Genetic (G) and environmental factors (E) play a critical role in the development of child behavioral problems. How G and E interact with each other is a hot topic in the field of child development. The present study aimed to explore how 5-HTTLPR polymorphism and maternal parenting stress interact with each other when impacting on child behavioral problems in China. 355 children and their parents participated in this study at the child age of 6 months. At 6 months old, maternal parenting stress, buccal cells from children, and demographic data were collected. 5-HTTLPR polymorphism was determined by polymerase chain reaction amplification. At 48 months old, the mother and father were invited again to report child behavioral problems, respectively. The results showed:(1) maternal parenting stress was positively linked with externalizing problems of boys with s/s and s/l genotypes, but not for boys with l/l genotype. This interaction was consisted with diathesis-stress model, indicating that the s/s and s/l genotypes were risk factors for boys to suffer from high parenting stress to have more externalizing problems; (2) maternal parenting stress was positively associated with internalizing problems of l/l-genotype girls, but not for s/s-and s/l-genotype girls. This interaction fit with diathesis-stress model, which indicated that the l/l genotype was a risk factor for girls to suffer from high parenting stress to have more internalizing problems.

Key words: 5-HTTLPR polymorphism, parenting stress, behavioral problems, G×E interaction, preschool period

CLC Number: 

  • B844
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