Psychological Development and Education ›› 2023, Vol. 39 ›› Issue (2): 276-285.doi: 10.16187/j.cnki.issn1001-4918.2023.02.14

Previous Articles     Next Articles

The Effect of Childhood Maltreatment on College Students’ Depressive Symptoms: The Mediating Role of Subjective Well-being and the Moderation Role of Gene

ZENG Zihao1, PENG Liyi1, ZHAN Lin2, LIU Shuangjin1, OUYANG Xiaoyou3, DING Daoqun1,4, LI Zhihua5, HU Yiqiu1,7, FANG Xiaoyi6   

  1. 1. School of Education Science, Hunan Normal University, Changsha 410081;
    2. Hunan Normal University Library, Changsha 410081;
    3. Hunan Mass Media College Trade Union Committee, Changsha 410100;
    4. Cognition and Human Behavior Key Laboratory of Hunan Province, Changsha 410081;
    5. School of Education, Hunan University of Science and Technology, Xiangtan 411201;
    6. Institute of Developmental Psychology, Beijing Normal University, Beijing 100875;
    7. School of Psychology, Hainan Normal University, Haikou 571158
  • Published:2023-03-11

RichHTML

PDF (PC)

Abstract: The current study constructed a moderated mediation model exploring the relationship among childhood maltreatment on college students’ depressive symptoms. A total of 301 college students (74 boys and 227 girls) participated in this investigation. After given informed consents, they completed Center for Epidemiological Studies Depression Scale, The Chinese Version of Childhood Trauma and Questionnaire and Subjective Well-being Scale. Professional nurses extracted 2.5-ml venous blood in EDTA anticoagulant tube (blood∶EDTA = 5∶1) from the participants in the study, then placed it in the refrigerator (-70 ℃), and extracted DNA and parting after three months. The results indicated that: (1) Childhood maltreatment was significantly positively correlated with college students’ depressive symptoms, and subjective well-being was significantly negatively correlated with childhood maltreatment and college students’ depressive symptoms; (2) Subjective well-being played a mediating role in the relationship between childhood maltreatment and college students’ depressive symptoms; (3) MAOA gene rs6323 homozygous G/G than G/T and T/T carriers reduced suffering from depression. MAOA gene rs6323 and TPH2 gene rs17110747 polymorphism moderated the indirect path from subjective well-being and college students’ depressive symptoms. Compared with rs6323 polymorphism G/G and T/T (rs17110747 polymorphism G/G and G/T) genotypes, subjective well-being of individuals with G/T (A/A) genotype had a stronger negative prediction of depressive symptoms.

Key words: childhood maltreatment, subjective well-being, college students’ depressive symptoms, MAOA gene rs6323, TPH2 gene rs17110747

CLC Number: 

  • B844
Aghababaei, N., Bragatti, J. A., Bandeira, I. C., de Carvalho, A. M., Abujamra, A. L., Leistner-Segal, S.,&Bianchin, M. M.(2014). Tryptophan hydroxylase 2(TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.Epilepsy&Behavior, 32, 59-63.
Agnew-Blais, J.,&Danese, A.(2016). Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder:A systematic review and meta-analysis. The Lancet Psychiatry, 3(4), 342-349.
Badr, H. E., Naser, J., Al-Zaabi, A., Al-Saeedi, A., Al-Munefi, K., Al-Houli, S.,&Al-Rashidi, D.(2018). Childhood maltreatment:A predictor of mental health problems among adolescents and young adults. Child Abuse&Neglect, 80, 161-171.
Beach, S. R. H., Brody, G. H., Gunter, T. D., Packer, H., Wernett, P.,&Philibert, R. A.(2010). Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder.Journal of Family Psychology, 24(1), 12-20.
Beck, A. T.,&Weishaar, M. E.(2000). Cognitive therapy. In R. J. Corsini&D. Wedding (Eds.),Current psychotherapies(pp. 241-272). Itasca, IL:F.E. Peacock.
Belmaker, R. H.,&Agam, G.(2008). Mechanisms of disease:Major depressive disorder.The New England Journal of Medicine, 358(1), 55-68.
Bland, J. M.,&Altman, D. G.(1997). Statistics notes:Cronbach's alpha. BMJ, 314, 572.
Byrd, A. L.,&Manuck, S. B.(2014). MAOA, childhood maltreatment, and antisocial behavior:Meta-analysis of a gene-environment interaction.Biological Psychiatry, 75(1), 9-17.
Capistrant, B. D., Friedemann-Sánchez, G., Novak, L. K., Zuijdwijk, C., Ogle, G. D.,&Pendsey, S.(2017). Mental health and well-being among type 1 diabetes caregivers in India:Evidence from the IDREAM study.Diabetes Research and Clinical Practice, 134, 168-177.
Caspi, A.(2003). Influence of life stress on depression:Moderation by a polymorphism in the 5-htt gene.Science, 301(5631), 386-389.
Cicchetti, D., Rogosch, F. A.,&Sturge-Apple, M. L.(2007). Interactions of child maltreatment and serotonin transporter and monoamine oxidase a polymorphisms:Depressive symptomatology among adolescents from low socioeconomic status backgrounds.Development and Psychopathology, 19(04), 1161-1180.
Cohen, J.(1988).Statistical power analysis for the behavioral sciences. Routledge.
Comasco, E., Sylvén, S. M., Papadopoulos, F. C., Sundström-Poromaa, I., Oreland, L.,&Skalkidou, A.(2011). Postpartum depression symptoms:A case-control study on monoaminergic functional polymorphisms and environmental stressors.Psychiatric Genetics, 21(1), 19-28.
Diener, E., Suh, E. M., Lucas, R. E.,&Smith, H. L.(1999). Subjective well-being:three decades of progress. Psychological Bulletin, 125(2), 276-302.
Dunn, E. C., Uddin, M., Subramanian, S. V., Smoller, J. W., Galea, S.,&Koenen, K. C.(2011). Research review:Gene-environment interaction research in youth depression-a systematic review with recommendations for future research.Journal of Child Psychology and Psychiatry, 52(12), 1223-1238.
Fan, M., Liu, B., Jiang, T., Jiang, X., Zhao, H.,&Zhang, J.(2010). Meta-analysis of the association between the monoamine oxidase-a gene and mood disorders.Psychiatric Genetics, 20(1), 1-7.
Felitti, V. J., Anda, R. F, Nordenberg, D., Williamson, D. F.,&Marks, J. S.(2019). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults:The adverse childhood experiences (ace) study.American Journal of Preventive Medicine, 56(6), 774-786.
Gilman, S. E., Sucha, E., Kingsbury, M., Horton, N. J., Murphy, J. M.,&Colman, I.(2017). Depression and mortality in a longitudinal study:1952-2011.Canadian Medical Association journal. 189(42), E1304-E1310.
Greger, H. K., Myhre, A. K., Klöckner, C. A.,&Jozefiak, T.(2017). Childhood maltreatment, psychopathology and well-being:The mediator role of global self-esteem, attachment difficulties and substance use. Child Abuse&Neglect, 70, 122-133.
Hammen, C.(2018). Risk factors for depression:An autobiographical review. Annual Review of Clinical Psychology, 14, 1-28.
Jansson, M., McCarthy, S., Sullivan, P. F., Dickman, P., Andersson, B., Oreland, L., … Pedersen, N. L.(2005). MAOA haplotypes associated with thrombocyte-MAO activity. BMC Genetics, 6(1), 46.
Jaye Capretto, J.(2020). Developmental timing of childhood physical and sexual maltreatment predicts adult depression and post-traumatic stress symptoms.Journal of Interpersonal Violence, 35(13-14), 2558-2582.
Kaufman, J., Yang, B. Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., … Gelemter, J.(2006). Brain-derived neurotrophic factor-5-httlpr gene interactions and environmental modifiers of depression in children.Biological Psychiatry, 59(8), 673-680.
Kifer, Y., Heller, D., Perunovic, W. Q. E.,&Galinsky, A. D.(2013). The good life of the powerful:The experience of power and authenticity enhances subjective well-being.Psychological Science, 24(3), 280-288.
Lamela, D., Jongenelen, I., Morais, A.,&Figueiredo, B.(2017). Cognitive-affective depression and somatic symptoms clusters are differentially associated with maternal parenting and coparenting.Journal of Affective Disorders, 219, 37-48.
Moreno, R. L., Godoy-Izquierdo, D., Vazquez Perez, M. L., García, A. P., Araque Serrano, F.,&Godoy Garcia, J. F.(2014). Multidimensional psychosocial profiles in the elderly and happiness:A cluster-based identification.Aging&Mental Health, 18(4), 489-503.
Nabavi, S. M., Daglia, M., Braidy, N.,&Nabavi, S. F.(2015). Natural products, micronutrients, and nutraceuticals for the treatment of depression:A short review.Nutritional Neuroscience, 20(3), 180-194.
Nanni, V., Uher, R.,&Danese, A.(2012). Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression:A meta-analysis.American Journal of Psychiatry, 169(2), 141-151.
Natsuaki, M. N., Biehl, M. C.,&Ge, X. J.(2010). Trajectories of depressed mood from early adolescence to young adulthood:The effects of pubertal timing and adolescent dating.Journal of Research on Adolescence, 19(1), 47-74.
Nelson, J., Klumparendt, A., Doebler, P.,&Ehring, T.(2017). Childhood maltreatment and characteristics of adult depression:Meta-analysis.The British Journal of Psychiatry, 210(2), 96-104.
Nikulina, V., Widom, C. S.,&Brzustowicz, L. M.(2011). Child abuse and neglect, monoamine oxidase a, and mental health outcomes:A prospective examination.Biological Psychiatry, 71(4),350-357.
Ottenhof, K. W., Sild, M., Lévesque, M. L., Ruhé, H. G.,&Booij, L.(2018). TPH2 polymorphisms across the spectrum of psychiatric morbidity:A systematic review and meta-analysis. Neuroscience&Biobehavioral Reviews, 92, 29-42.
Rivera, M., Gutiérrez, B., Molina, E., Torres-González, F., Bellón, J. A., Moreno-küstner, B., … Cervilla, J. A.(2009). High-activity variants of the umaoa polymorphism increase the risk for depression in a large primary care sample.American Journal of Medical Genetics, Part B, Neuropsychiatric Genetics:The Official Publication of the International Society of Psychiatric Genetics, 150B(3), 395-402.
Seligman, M. E. P.(2008). Positive health. Applied Psychology:An International Review, 57, 3-18.
Sheikh, M. A., Abelsen, B.,&Olsen, J. A.(2016). Differential recall bias, intermediate confounding, and mediation analysis in life course epidemiology:An analytic framework with empirical example.Frontiers in Psychology, 7, 1828.https://doi.org/10.3389/fpsyg.2016.01828
Sijtsma, K.(2009). On the use, the misuse, and the very limited usefulness of Cronbach's alpha.Psychometrika, 74(1), 107-120.
Smith, K.(2014). Mental health:A world of depression.Nature, 515, 180-181.
Starr, L. R., Hammen, C., Conway, C. C., Raposa, E.,&Brennan, P. A.(2014). Sensitizing effect of early adversity on depressive reactions to later proximal stress:Moderation by 5-HTTLPR and CRHR1 in a 20-year longitudinal study.Development and Psychopathology, 26(4Pt2), 1241-1254.
Tao, S., Chattun, M. R., Yan, R., Geng, J., Zhu, R., Shao, J., … Yao, Z.(2018). TPH-2 gene polymorphism in major depressive disorder patients with early-wakening symptom.Frontiers in Neuroscience, 12, 827.https://doi.org/10.3389/fnins.2018.00827
Teicher, M. H., Samson, J. A., Anderson, C. M.,&Ohashi, K.(2016). The effects of childhood maltreatment on brain structure, function and connectivity.Nature Reviews Neuroscience, 17(10), 652-666.
Tsai, S. J., Hong, C. J., Liou, Y. J., Younger, W. Y., Chen, T. J., Hou, S. J.,&Yen, F. C.(2009). Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Progress in Neuro-Psychopharmacology and Biological Psychiatry, 33(4), 637-641.
Wichers, M., Jacobs, N., Derom, C., Thiery, E.,&van Os, J.(2007). Depression:Too much negative affect or too little positive affect?Twin Research and Human Genetics, 10(S1), 19-20.
Yang, W., Xiong, G., Garrido, L. E., Zhang, J. X., Wang, M. C.,&Wang, C.(2018). Factor structure and criterion validity across the full scale and ten short forms of the CES-D among Chinese adolescents.Psychological Assessment, 30(9), 1186-1198.
Zhang, L., Li, Z., Chen, J., Li, X., Zhang, J.,&Belsky, J.(2016). The bdnf val66met polymorphism interacts with maternal parenting influencing adolescent depressive symptoms:Evidence of differential susceptibility model.Journal of Youth and Adolescence, 45(3), 471-483.
温忠麟,叶宝娟.(2014).有调节的中介模型检验方法:竞争还是替补?心理学报, 46(5), 714-726.
吴艳,温忠麟.(2011).结构方程建模中的题目打包策略.心理科学进展, 19(12), 1859-1867.
于增艳,赵阿勐,刘爱书.(2017).儿童期受虐经历与抑郁的元分析. 心理学报, 49(1), 40-49.
张洁旭,陈彦博,张克让,许琪,沈岩.(2009).单胺氧化酶A启动子可变数目重复序列多态性与中国北方汉族人群重性抑郁症的关联分析. 中国医学科学院学报, 31(6), 728-734.
张连云.(2006).抑郁、社会支持对师范大学生主观幸福感的影响. 中国健康心理学杂志,(05), 117-119.
赵幸福,张亚林,李龙飞,周云飞.(2005).儿童期虐待问卷中文版的信度及效度评估.中国临床康复,(16), 209-211.
中华人民共和国国家卫生健康委员会.(2020).国家卫生健康委办公厅关于探索开展抑郁症、老年痴呆防治特色服务工作的通知.取自http://www.nhc.gov.cn/jkj/s7914/202009/a63d8f82eb53451f97217bef0962b98f.shtml.
[1] TANG Yingying, LIN Xiuyun, YIN Jinxiu, HE Ting, ZHOU Shaojia, CAO Zhitao. Congruence and Incongruence of Mother-child Attachment and Grandmother-child Attachment: Links with Children’s Subjective Well-being [J]. Psychological Development and Education, 2023, 39(6): 859-868.
[2] PENG Haiyun, SHENG Liang, QIU Fanshuo, ZHOU Ziyan, XIN Sufei. Psychological Burden Reduction Starts from Dealing with Boredom: The Influencing Mechanism of Boredom Proneness on Subjective Well-being among Adolescents [J]. Psychological Development and Education, 2023, 39(6): 895-902.
[3] YUE Pengfei, ZHANG Jiaxin, BAI Xuejun. Life Events and Academic Procrastination among Middle School Students: A Moderated Mediation Model [J]. Psychological Development and Education, 2023, 39(2): 228-235.
[4] TIAN Weiyi, XU Jianjie, LYU Guanglin, WANG Yinan. Parental Self-esteem and Adolescents’ Subjective Well-being: The Chain Mediating Roles of Parent-adolescent Trust and Adolescents’ Self-esteem [J]. Psychological Development and Education, 2022, 38(3): 331-338.
[5] CHEN Bizhong, ZHENG Xue, SUN Xiaojun. The Impact of Social Media Self-control Failure on Subjective Well-being of Postgraduates and Its Mechanism [J]. Psychological Development and Education, 2021, 37(6): 882-888.
[6] YUAN Keman, LI Bailu, LIANG Lichan, BIAN Yufang. Cumulative Contextual Risk and Subjective Well-being in Migrant Children: The Compensatory Effect and Protective Effect of Individual Protective Factors [J]. Psychological Development and Education, 2021, 37(4): 546-557.
[7] NIU Kaining, LI Mei, ZHANG Xiangkui. The Relationship Between Adolescents' Friendship Quality and Subjective Well-being: A Meta-analysis [J]. Psychological Development and Education, 2021, 37(3): 407-418.
[8] CHEN ZiXun, WANG Hui, FENG Yingxue, LIU Xia. The Effects of Peer Victimization on Left-behind Adolescents' Subjective Well-being: The Roles of Self-esteem and Social Support [J]. Psychological Development and Education, 2020, 36(5): 605-614.
[9] CHI Wentao, SANG Qingsong, SHU Shouli. The Relationship between College Students' Major Intrinsic Motivation and Subjective Well-being: The Mediators of Major Engagement and Subjective Major Achievement [J]. Psychological Development and Education, 2020, 36(4): 477-485.
[10] HENG Shupeng, ZHAO Huanfang, NIU Gengfeng, ZHOU Zongkui. Likes on WeChat Moments and Subjective Well-Being: A Mediated Moderation Model [J]. Psychological Development and Education, 2020, 36(3): 341-349.
[11] GUO Jinjin, NIU Lu, XIE Xiaochun, WANG Pengcheng, LEI Li. The Association between “Show off Love” and Subjective Well-being of Spectators: The Mediating Role of Self-esteem and the Moderating Role of Attachment [J]. Psychological Development and Education, 2020, 36(3): 359-366.
[12] WU Yuting, YUAN Xin, WANG Yuqing, ZHU Hui, MAO Yelin, JIN Cancan. Influence of Square Dance Organizational Climate towards Elderly's Subjective Well-being: The Mediating Effect of Group Identification and Self-esteem [J]. Psychological Development and Education, 2019, 35(5): 624-631.
[13] ZHANG Xingxu, GUO Haiying, LIN Danhua. A Study on the Relationship between Parent-child, Peer, Teacher-student Relations and Subjective Well-being of Adolescents [J]. Psychological Development and Education, 2019, 35(4): 458-466.
[14] NIU Yubai, HAO Zesheng, WANG Renzhen, HONG Fang. The Relationship between Optimism, Perceived Social Support and Subjective Well-being of The Elderly: The Mediating Role of Control Strategies [J]. Psychological Development and Education, 2019, 35(2): 227-235.
[15] LIAN Kunyu, XIE Shanshan, LIN Rongmao. The Relationship between Vocational Personality and Subjective Well-Being in Elementary and Secondary School Teachers: The Mediating Role of Work Engagement [J]. Psychological Development and Education, 2017, 33(6): 700-707.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Psychological Development and Education
Supported by Beijing Magtech Co.Ltd