学校人际关系与血清素系统多基因累积遗传风险对青少年抑郁的影响

doi:10.16187/j.cnki.issn1001-4918.2025.03.14

摘要/Abstract

摘要： 基于抑郁的人际关系理论与进化模型,采用问卷法和DNA分型技术,对525名青少年进行为期两年的追踪调查,选取关键变量学校人际关系,挫败感和血清素系统多基因构建一个有调节的中介模型,考察遗传与环境的交互作用对抑郁的影响。结果显示:(1)学校人际关系可以显著预测青少年抑郁;(2)挫败感在学校人际关系对青少年抑郁影响中起中介作用;(3)多基因风险评分(Polygenic Risk Score, PRS)调节同伴关系和挫败感对青少年抑郁的影响,具体表现为,随着PRS得分的增加,挫败感对青少年的影响增强,斜率增加,有着更高的抑郁风险;同伴关系对抑郁的影响表现出类似情况,斜率绝对值增加,负向预测加强,即抑郁得分更低,支持差别易感性模型;(4)敏感性分析结果显示,TPH2基因rs4570625多态性G等位基因是青少年抑郁的重要候选基因,且相比单基因研究,多基因与环境的交互作用对抑郁的解释力和稳定性更强。

关键词: 青少年抑郁, 学校人际关系, 挫败感, 血清素, 多基因

Abstract: Based on the interpersonal theory and evolutionary model of depression, a two-year follow-up survey was conducted with 525 adolescents using questionnaire method and DNA typing technique. Key variables (school interpersonal relationship, defeat and serotonin system polygenes) were selected to construct a moderated mediation model to examine the effect of genetic-environmental interactions on depression. The results showed that: (1) School interpersonal relationship predicted adolescent depression; (2) Defeat mediated the effect between school interpersonal relationship and adolescent depression; (3) PRS moderated the effect of peer relationship and defeat on adolescent depression, specifically, as PRS scores increased, the slope of defeat on adolescents increased and the effect enhanced; peer relationship on depression showed a similar picture with an increase in the absolute value of slope and enhanced negative prediction, supporting the differential susceptibility model; (4) The results of sensitivity analysis showed that the TPH2 gene rs4570625 polymorphism was an important candidate gene for adolescent depression. The interaction between multi-gene with the environment have greater explanatory power and stability for depression than single gene.

Key words: adolescent depression, school interpersonal relationships, defeat, serotonin, polygenic

中图分类号:

B844

曾子豪, 胡义秋, 刘双金, 彭丽仪, 杨琴, 王宏才, 何震, 姚星星. 学校人际关系与血清素系统多基因累积遗传风险对青少年抑郁的影响[J]. 心理发展与教育, 2025, 41(3): 436-447.

ZENG Zihao, HU Yiqiu, LIU Shuangjin, PENG Liyi, YANG Qin, WANG Hongcai, HE Zhen, YAO Xingxing. School Interpersonal Relationship and Cumulative Polygenic Genetic Risk of Serotonin System on Adolescent Depression[J]. Psychological Development and Education, 2025, 41(3): 436-447.

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