Psychological Development and Education ›› 2021, Vol. 37 ›› Issue (2): 275-287.doi: 10.16187/j.cnki.issn1001-4918.2021.02.15

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The Genetic Basis of Antisocial Behavior: Gene Polymorphism and DNA Methylation

JIANG Zhenli1,2, ZHANG Minghao1   

  1. 1. School of Educational Science, Ludong University, Yantai 264025;
    2. College of Safety and Environ mental Enginering, Shandong University of Science and Technology, Qingdao 266590
  • Published:2021-03-23

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Abstract: Antisocial behavior is influenced by both gene and environment. Molecular genetics and neurobiological studies have found that gene polymorphisms and DNA methylation affect structure and function of brain, as well as the production and release of neurotransmitters, all of which can impact antisocial behavior. In this paper, the association between antisocial behavior and eight candidate genes, including 5-HTT, MAOA, DRD4, etc., is reviewed from the perspectives of gene polymorphism and DNA methylation. It is proposed that future studies should explore how genes, brain and neurotransmitters affect antisocial behavior together. Meanwhile, research on the combined effects of multiple loci, the interaction between gene polymorphism and DNA methylation, as well as the interaction between positive environment and genes should be expanded, so as to comprehensively investigate the genetic basis of antisocial behavior, and to prevent antisocial behavior more effectively.

Key words: antisocial behavior, gene polymorphism, DNA methylation, brain

CLC Number: 

  • B844
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