Psychological Development and Education ›› 2010, Vol. 26 ›› Issue (2): 215-224.

Previous Articles    

Genetic Factors in Temperament:Single Nucleotide Polymorphism Research

ZHANG Ming-hao1, CHEN Xin-yin2, LU Zu-hong1   

  1. 1. Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Research Center of Learning Science, Southeast University, Nanjing 210096, China;
    2. Department of psychology, University of Western Ontario, London, Ontario, N6A3K7
  • Online:2010-03-15 Published:2010-03-15

PDF (PC)

Abstract: Temperament represents the typical pattern of individual behavioral and emotional reactions to stimuli, which is the basis for the development of human personality characteristics.Alarge number of research findings have indicated that genetic factors play an important role in exp laining individual differences in temperament. Relations between serotonin transporter genes and dopam ine D4 receptor genes,such as single nucleotide polymorphisms and anxiety-related and novelty seeking traits were first examined in adults over 10 years ago. Since then,numerous candidate genes have been tested for their association with personality traits.However,most of the existing studies in this area have focused on adult personality traits;there are few studies about genes and temperament in children.Because child temperament and adult personality traits may share certain biological processes,genes that related to adult personality traits may have similar effects on child temperament.In this paper,candidate genes that contributed to child temperament are discussed based on the research involving both adult personality traits and child characteristics.

Key words: temperament, dopamine, serotonin, candidate genes

CLC Number: 

  • B844.1
[1] Auerbach,J.,Faroy,M.,Ebstein,R.,Kahana,M.,&Levine,J.(2001).The association of the dopamine D4 receptor gene(DRD4) and the serotonin transporter promoter gene(5-HTTLPR)with temperament in 12-monthold infants.The Journal of Child Psychology and Psychiatry and Allied Disciplines,42(06),777-783.
[2] Benjam in,J.,L i,L.,Patterson,C.,Greenberg,B.,Murphy,D.,&Hamer,D.(1996).Population and fam ilial association between the D4 dopamine receptor gene and measures of novelty seeking.Nature Genetics,12(1),81-84.
[3] Benjam in,J.,O sher,Y.,L ichtenberg,P.,Bachner-Melman,R.,Gritsenko,.I,Kotler,M.,et al.(2000).An interaction between the catechol Omethyltransferase and serotonin transporter promoter region polymorphisms contributes to tridimensional personality questionnaire persistence scores in normal subjects. Neuropsychobiology,41(1),48-53.
[4] Blatny,M.,Jelinek,M.,&Osecka,T.(2007).A ssertive toddler, self-efficacious adult:Child temperament p redicts personality over forty years.Personality and Individual Differences,43(8),2127-2136.
[5] Bookman,E.,Taylor,R.,Adams-Campbell,L.,&Kittles,R.(2002).DRD4 promoter SNPs and gender effects on Extraversion in African Americans.Molecular Psychiatry,7(7),786-789.
[6] Canli,T.,Congdon,E.,Gutknecht,L.,Constable,R.,&Lesch,K.(2005).Amygdala responsiveness is modulated by tryptophan hydroxylase 22 genevariation.Journal of Neural Transmission,112(11),1479-1485.
[7] Casp i,A.(2000).The child is father of the man:Personality continuities from childhood to adulthood.Journal of Personality and Social Psychology,78(1),158-172.
[8] Cloninger,C.,Svrakic,D.,&Przybeck,T.(1993).A psychobiological model of temperament and character.Archieves of General Psychiatry, 50(12),975-990.
[9] Cooccaro,C.,Svrakic,D.,Sheline,Y.,&Berman,M.(1997). Impulsive aggression in personality disorder correlates with platelet 5-HT-sub(2A)recep tor binding.N europsychophatm acology,16(3),211-216.
[10] Damberg,M.,Bergg rd,C.,Mattila-Evenden,M.,Rylander,G., Forslund,K.,Garpenstrand,H.,et al.(2003).Transcrip tion factor AP-2βgenotype associated with anxiety-related personality traits in women.Areplication study.Neuropsychobiology,48(4),169-175.
[11] Damberg,M.,Garpenstrand,H.,Hallman,J.,&O reland,L.(2001).Genetic mechanisms of behavior-don't forget about the transcription factors.Molecular Psychiatry,6(5),503-510.
[12] Dragan,W.,&Oniszczenko,W.(2005).Polymorphisms in the serotonin transporter gene and their relationship to two temperamental traits measured by the Formal Characteristics of Behavior-Temperament Inventory:activity and emotional reactivity.Neuropsychobiology,51(4),269-274.
[13] Dragan,W.,&Oniszczenko,W.(2006).A ssociation of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population.Neuropsychobiology,54(1),45-50.
[14] Ebstein,R.,Levine,J.,Geller,V.,Auerbach,J.,Gritsenko,.I,&Belmaker,R.(1998).Dopam ine D4 recep tor and serotonin transporter promoter in the determination of neonatal temperament. Molecular Psychiatry,3(3),238-246.
[15] Ebstein,R.,Nemanov,L.,Klotz,I.,Gritsenko,.I,&Belmaker,R.(1997)Additional evidence for an association between the dopam ine D4 recep tor(D4DR)exon III repeat polymorphism and the human personality trait of Novelty Seeking.Molecular Psychiatry,2(6),472-477.
[16] Ebstein,R.,Novick,O.,Umansky,R.,Priel,B.,O sher,Y.,Blaine,D.,et al.(1996).Dopamine D4 receptor(D4DR)exon III polymorphism associated with the human personality trait of novelty seeking.Nature Genetics,12(1),78-80.
[17] Ebstein,R.,Segman,R.,Benjam in,J.,O sher,Y.,Nemanov,L.,&Belmaker,R.(1997).5-HTC(HTRC)serotonin receptor gene polymorphism associated with the human personality trait of reward dependence:Interaction with dopamine D4 receptor(D4DR)and dopam ine D3 receptor(D3DR)polymorphisms.American Journal of MedicalGenetics,74(1),65-72.
[18] Ekelund,J.,Suhonen,J.,J rvelin,M.R.,Peltonen,L.,& Lichtermann,D.(2001).No association of the 2521 C/T polymorphism in the promoter of DRD4 with novelty seeking.Molecular Psychiatry,6(6),618-619.
[19] Enoch,M.,Xu,K.,Ferro,E.,Harris,C.,&Goldman,D.(2003).Genetic origins of anxiety in women:a role for a functional catechol 2O-methyltransferase polymorphism.Psychiatric Genetics,13(1),33-41.
[20] Fox,N.,Nichols,K.,Henderson,H.,Rubin,K.,Schmidt,L.,Hamer,D.,et al.(2005).Evidence for a gene-environment interaction in predicting behavioral inhibition in middle child hood. Psychological Science,16(12),921-926.
[21] Garpenstrand,H.,Norton,N.,Damberg,M.,Rylander,G.,Forslund,K.,Mattila-Evenden,M.,et al.(2000).A regulatory monoamine oxidase a promoter polymorphism and personality traits. Neuropsychobiology,46(4),190-193.
[22] Gillihan,S.,Farah,M.,Sankoorikal,G.,Breland,J.,&Brodkin, E.(2007).A ssociation between serotonin transporter genotype and extraversion.Psychiatric Genetics,17(6),351-354.
[23] Gustavsson,J.,N then,M.,Joensson,E.,Neidt,H.,Forslund, K.,Rylander,G.,et al.(1999).No association between serotonin transporter gene polymorphisms and personality traits.American Journal of Medical Genetics,88(4),430-436.
[24] Hünnerkopf,R.,Strobel,A.,Gutknecht,L.,B rocke,B.,&Lesch, K.(2007).Interaction between BDNF Val66 Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharm acology,32(12),2552-2560.
[25] Hayden,E.,Dougherty,L.,Maloney,B.,Emily Durbin,C.,Olino, T.,Nurnberger J r,J.,et al.(2007).Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: amultimethod association study.Psychiatric Genetics,17(3),135-142.
[26] Ishii,G.,Suzuki,A.,O shino,S.,Shiraishi,H.,Matsumoto,Y., Otani,K.,et al.(2007).A ssociation study of catechol 2O-methyltransferase Val158 Met polymorphism with personality traits in Japanese healthy volunteers.European Psychiatry,22(7),462-465.
[27] Ishii,G.,Suzuki,A.,Oshino,S.,Shiraishi,H.,&Otani,K.(2007).CYP2C19 polymorphism affects personality traits of Japanese females.Neuroscience Letters,411(1),77-80.
[28] Jnsson,E.,N then,M.,Gustavsson,J.,Neidt,H.,Forslund,K., Mattila-Evenden,M.,et al.(1998).Lack of association between dopamine D4 recep tor gene and personality traits.Psychological Medicine,28(04),985-989.
[29] Jnsson,E.,N then,M.,Gustavsson,J.,Neidt,H.,Brene,S.,Tylec,A.,et al.(1997).Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms(Vo.l154,pp.697-699):Am Psychiatric Assoc.
[30] Jiang,X.,Xu,K.,Hoberman,J.,Tian,F.,Marko,A.,Waheed,J.,et al.(2005).BDNF variation and mood disorders:a novel functional promoter polymorphism and Val66 Met are associated with anxiety but have opposing effects.Neuropsychopharm acology,30(7), 1353-1361.
[31] Kühn,K.,Meyer,K.,N then,M.,Gaensicke,M., Papassotiropoulos,A.,&Maier,W.(1999).A llelic variants of dopamine recep tor D 4(DRD4)and serotonin receptor 5 HTc(HTRc)and temperament factors:Replication tests.American Journal of medical Genetics,88(2),168-172.
[32] Keltikangas-J rvinen,L.,Puttonen,S.,Kivimaki,M.,Rontu,R.,&Lehtimaki,T.(2006).Cloninger's temperament dimensions and epidermal growth factor A61G polymorphism in Finnish adults.Gene Bra in and Behavior,5(1),11-18.
[33] Kim,S.,Kim,Y.,Kim,C.,&Lee,H.(2006).Lack of association between polymorphisms of the dopam ine receptor D4 and dopamine transporter genes and personality traits in a Korean population.Yonsei Medical Journal,47(6),787-792.
[34] Lakatos,K.,Nemoda,Z.,Birkas,E.,Ronai,Z.,Kovacs,E.,Ney, K.,et al.(2003).A ssociation of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants'response to novelty.Molecular Psychiatry,8(1),90-97.
[35] Lee,B.,Yang,J.,Lee,S.,Kim,S.,Joe,S.,Jung,.I,et al.(2008).An interaction between the norep inephrine transporter and monoam ine oxidase A polymorphisms,and novelty-seeking personality traits in Korean females.Progress in Neu ropsychopharm acology& Biological Psychiatry,32(1),238-242.
[36] Manuck,S.,Flory,J.,Ferrell,R.,Mann,J.,&Muldoon,M.(2000).Aregulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression,impulsivity,and central nervous system serotonergic responsivity.Psychiatry Research,95(1),9-23.
[37] Melke,J.,Westberg,L.,Nilsson,S.,Landen,M.,Soderstrom,H.,Baghaei,F.,et al.(2003).A polymorphism in the serotonin receptor 3A(HTR3A)gene and its association with harm avoidance in women.Archives of General Psychiatry,60(10),1017-1023.
[38] Munafò,M.,Yalcin,B.,Willis-Owen,S.,&Flint,J.(2008).A ssociation of the dopam ine D4 receptor(DRD4)gene and approach-related personality traits:meta-analysis and new data.Biological Psychiatry,63(2),197-206.
[39] Nilsson,K.,Damberg,M.,hrvik,J.,Leppert,J.,Lindstrm,L.,Anckars ter,H.,et al.(2007).Genes encoding for AP2-βand the serotonin transporter are associated with the personality character spiritual acceptance.Neuroscience Letters,411(3),233-237.
[40] Noble,E.,Ozkaragoz,T.,Ritchie,T.,Zhang,X.,Belin,T.,&Sparkes,R.(1998).D2 and D4 dopamine receptor polymorphisms and personality.American Journal of Medical Genetics-Neuropsychiatric Genetics,81(3),257-267.
[41] Noblett,K.,&Coccaro,E.(2005).Molecular genetics of personality. Current Psychiatry Reports,7(1),73-80.
[42] Okuyama,Y.,Ishiguro,H.,Nankai,M.,Shibuya,H.,Watanabe,A.,&A rinami,T.(2000).Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait.Molecular Psychiatry,5(1),64-69.
[43] Osher,Y.,Hamer,D.,&Benjam in,J.(2000).A ssociation and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Molecular Psychiatry,5(2),216-219.
[44] Persson,M.,W assermann,D.,Geijer,T.,Frisch,A.,Rockah,R.,Michaelovsky,E.,et al.(2000).Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers.European Archives of Psychiatry and Clinical Neuroscience,250(4),203-206.
[45] Plomin,R.,Chipuer,H.,&Loehlin,J.(1997).Behavioral genetics and personality.in Pervin Lawrence A,Handbook of personality:Theory and research.New York:Guilford Press,225-243.
[46] Reuter,M.,&Hennig,J.(2005).Association of the functional catechol-O-methyltransferase VAL158 MET polymorphism with the personality trait of extraversion.Neuroreport,16(10),1135-1138.
[47] Reuter,M.,Ott,U.,Vaitl,D.,&Hennig,J.(2007).Impaired executive control is associated with a variation in the promoter region of the tryp tophan hydroxylase 2 gene.Journal of Cognitive N euroscience,19(3),401-408.
[48] Rothbart,M.(1989).Temperament and development.Temperament in childhood,187-247.
[49] Samochowiec,J.,Syrek,S.,Michal,P.,Ryzewska-Wódecka,A.,Samochowiec,A.,Horodnicki,J.,et al.(2004).Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers.Neuropsychobiology,50(2),174-181.
[50] Savitz,J.,&Ramesar,R.(2004).Genetic variants implicated in personality:Areview of the more promising candidates.American Journal of Medical Genetics,131(1),20-32.
[51] Schultz,W.(2002).Getting formal with dopamine and reward. Neuron,36(2),241-263.
[52] Serretti,A.,Calati,R.,Giegling,.I,Hartmann,A.,Mller,H., Colombo,C.,et al.(2007).5-HTA SNPs and the temperament and character inventory.Progress in Neurop sychopharmacology& Biological Psychiatry,31(6),1275-1281.
[53] Shiraishi,H.,Suzuki,A.,Fukasawa,T.,Aoshima,T.,U jiie,Y.,Ishii,G.,et al.(2006).Monoamine oxidase Agene promoter polymorphism affects novelty seeking and reward dependence in healthy study participants.Psychiatric Genetics,16(2),55-58.
[54] Staner,L.,Hilger,C.,Hentges,F.,Monreal,J.,Hoffmann,A., Couturier,M.,et al.(1998).A ssociation between novelty-seeking and the dopamine D3 receptor gene in bipolar patients:A preliminary report.American Journal of Medical Genetics,81(2),192-194.
[55] Thomas,A.,&Chess,S.(1977)Temperament and development.
[56] Brunner/Mazel Publisher Yasui-Furukori,N.,Kaneda,A.,Iwashima,K.,Saito,M.,Nakagami,T.,Tsuchimine,S.,et al.(2007).A ssociation between cytochrome P450(CYP)2C19 polymorphisms and harm avoidance in Japanese.American Journal of Medical Genetics.Part B,144(6),724-727.
[57] 郭贞美,吴康敏,尚佳,谭平平,廖淼,张林.(2002).DRD4第3外显子48bp可变重复序列多态性与幼儿气体的相关研究.中华医学遗传学杂志,9(6),536-539.
[58] 张雨青.(1997).儿童气质和人格研究领域的新进展.心理学动态,15(4),28-32.
[1] LIU Shuang, LI Mei, FENG Xiaohang, ZHANG Xiangkui. A Longitudinal Study of Mastery Motivation and Competence in Early Childhood: The Moderating Effects of Types of Task and Temperament [J]. Psychological Development and Education, 2023, 39(2): 161-172.
[2] WANG Xinghua, HONG Huifang, ZHU Ruiling. The Relationship between Mother-child Interaction and Executive Function of 2~3-year-old Children: Moderating Effect of Children's Temperament [J]. Psychological Development and Education, 2021, 37(6): 784-791.
[3] LIU Shuang, SUN Yang, ZHANG Xiangkui. The Relationships between Mastery Motivation,Temperament and Competence of Young Children [J]. Psychological Development and Education, 2016, 32(3): 265-275.
[4] SUN Yan, MA Yanan, YANG Lizhu. The Impacts of Parental Educational Values On Children's Personality: A Moderated Mediation Model [J]. Psychological Development and Education, 2015, 31(5): 522-530.
[5] JI Lin-qin, ZHANG Ying-chun, ZHANG Liang, ZHAO Shu-juan, ZHANG Wen-xin. The Relationship of Temperament, Paternal Parenting, and Adolescents’ General Self-concept in Early Adolescence [J]. Psychological Development and Education, 2012, 28(6): 595-602.
[6] WANG Yan-hui, ZHANG Wei, LI Dong-ping, LI Dan-li, ZHANG Xiao-li. Temperament and Adolescent Tobacco and Alcohol Use: A Test of Interaction Effects [J]. Psychological Development and Education, 2012, 28(3): 292-300.
[7] LIU Wen, PENG Fei-fei. Self-regulation of Preschool Children and its Relations with Temperament [J]. Psychological Development and Education, 2010, 26(3): 245-250.
[8] LIU Wen, PENG Fei-fei. Self-regulation of Preschool Children and its Relations with Temperament [J]. Psychological Development and Education, 2010, 26(3): 245-250.
[9] LIU Wen, PENG Fei-fei. Self-regulation of Preschool Children and its Relations with Temperament [J]. Psychological Development and Education, 2010, 26(3): 245-250.
[10] DENG Li-fang, XU Qian, ZHENG Ri-chang. Researches Into the Relationships among Temperaments, Parental Rearing Patterns and Loneliness in College Students [J]. Psychological Development and Education, 2006, 22(3): 53-59.
[11] LIU Zhi-jun, WANG Hai-mei, SUN Ling, YIN Jun-li, JIA Xiu-zhen. Children’s Temperament, Parents’ Rearing Styles and Their Language Expression Development in Strange Environment [J]. Psychological Development and Education, 2005, 21(1): 26-30.
[12] YU Feng-ru, CHEN Hui-chang, HOU Jing, CHEN Xing-yin. Influencing Factors of Autobiographical Memory of 4 Years old Chidren [J]. Psychological Development and Education, 2002, 17(3): 40-45.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
Copyright 2018 © Editorial office of Psychological Development and Education
Supported by Beijing Magtech Co.Ltd